The Zn- or Cu-Thionein Character of a Metallothionein Determines Its Metal Load When Synthesized in Physiological (Metal-Unsupplemented) Conditions
Joint Authors
Palacios, Òscar
Atrian, Sílvia
Capdevila, Mercè
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present work comprises the recombinant synthesis of four metallothioneins (MTs) in metal-unsupplemented cultures and the characterization of the recovered metal complexes by means of analytical and spectrometric techniques.
The four MTs are two Drosophila (MtnA and MtnB), one yeast (Crs5), and one mouse (mMT1) metallothionein isoforms.
These four MTs exhibit distinct metal binding preferences, from a clear Cu-thionein character to a definite Zn-thionein nature, respectively.
Although in all cases, the only metal ion present in the purified complexes is Zn2+, our results highlight an inherently different behaviour of those two types of MTs, in conditions that would mimic their synthesis in physiological environments.
Therefore, intrinsically different roles can be hypothesized for the constitutively-produced MT peptides in the absence of any metal overload, depending on their Zn- or Cu-thionein character.
American Psychological Association (APA)
Capdevila, Mercè& Palacios, Òscar& Atrian, Sílvia. 2010. The Zn- or Cu-Thionein Character of a Metallothionein Determines Its Metal Load When Synthesized in Physiological (Metal-Unsupplemented) Conditions. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-480041
Modern Language Association (MLA)
Capdevila, Mercè…[et al.]. The Zn- or Cu-Thionein Character of a Metallothionein Determines Its Metal Load When Synthesized in Physiological (Metal-Unsupplemented) Conditions. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-480041
American Medical Association (AMA)
Capdevila, Mercè& Palacios, Òscar& Atrian, Sílvia. The Zn- or Cu-Thionein Character of a Metallothionein Determines Its Metal Load When Synthesized in Physiological (Metal-Unsupplemented) Conditions. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-480041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480041