Alzheimer's Disease and Metals : A Review of the Involvement of Cellular Membrane Receptors in Metallosignalling
Joint Authors
Barnham, Kevin J.
Amadoruge, Pavithra C.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer's disease (AD) is a debilitating form of dementia.
The hallmark protein associated with the disease is the amyloid beta (Aβ) peptide.
Aggregation of Aβ has been shown to depend on interactions with metals.
The recent studies now demonstrate that metals also play additional important roles in the disease process.
Consequently, there may be benefit from modulating metal homeostasis.
However, the role and subcellular location of metals within neurons is not well understood.
There is growing evidence to suggest that metals can act at the site of cellular membrane receptors and affect cellular signaling by modulating the signal transduction of those receptors.
The glutamatergic and cholinergic receptor systems, both well-known neurotransmitter systems affected in AD, have well-documented metal interactions, as do the tropomyosin-receptor kinase (Trk) family of receptors and the epidermal growth factor (EGF) receptor.
In this paper, the metal interactions with these membrane receptor systems will be explored and thus the potential for membrane receptors as an intervention point in AD will be assessed.
American Psychological Association (APA)
Amadoruge, Pavithra C.& Barnham, Kevin J.. 2011. Alzheimer's Disease and Metals : A Review of the Involvement of Cellular Membrane Receptors in Metallosignalling. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480070
Modern Language Association (MLA)
Amadoruge, Pavithra C.& Barnham, Kevin J.. Alzheimer's Disease and Metals : A Review of the Involvement of Cellular Membrane Receptors in Metallosignalling. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-480070
American Medical Association (AMA)
Amadoruge, Pavithra C.& Barnham, Kevin J.. Alzheimer's Disease and Metals : A Review of the Involvement of Cellular Membrane Receptors in Metallosignalling. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480070