A Simple Method to Detect Recovery of Glomerular Filtration Rate following Acute Kidney Injury
Joint Authors
Pickering, John W.
Mellas, John
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In acute kidney injury (AKI), elevated plasma creatinine is diagnostic of an earlier loss of glomerular filtration rate (GFR) but not of the concomitant GFR.
Only subsequent creatinine changes will inform if GFR had already recovered or not.
We hypothesized that the creatinine excretion rate to production rate ratio would provide this information.
A retrospective analysis of 482 critically ill patients from two intensive care units (ICU) is shown.
Plasma creatinine was measured on ICU entry and 12 hours later.
Four-hour creatinine excretion rates (E) were measured on entry.
Creatinine production rates were estimated (eG).
The ability of the ratio E/eG to predict a decrease in plasma creatinine concentration, identify recovered AKI (≥0.3 mg/dL decrease), and predict AKI (≥0.3 mg/dL increase) was assessed by the area under the receiver operator characteristic curves (AUC).
There was a linear relationship between reduced creatinine concentration and E/eG (r2=0.15; P<0.0001).
E/eG predicted a decrease in creatinine (AUC 0.70 (0.65 to 0.74)), identified recovered AKI (0.75 (0.67 to 0.84)), and predicted AKI (0.80 (0.73 to 0.86)).
A ratio of the rates of creatinine excretion to estimated production much less than 1 indicated a concomitant GFR below baseline, whereas a ratio much more than 1 indicated a recovering or recovered GFR.
American Psychological Association (APA)
Pickering, John W.& Mellas, John. 2014. A Simple Method to Detect Recovery of Glomerular Filtration Rate following Acute Kidney Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480071
Modern Language Association (MLA)
Pickering, John W.& Mellas, John. A Simple Method to Detect Recovery of Glomerular Filtration Rate following Acute Kidney Injury. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-480071
American Medical Association (AMA)
Pickering, John W.& Mellas, John. A Simple Method to Detect Recovery of Glomerular Filtration Rate following Acute Kidney Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480071