The Neuroprotective Effect of Gugijihwang-Tang on Trimethyltin-Induced Memory Dysfunction in the Rat
Joint Authors
Jung, Eun-Yee
Shim, Insop
Cho, Seung-Hun
Bae, Hyunsu
Lee, Mi-Sook
Ahn, Chang Joon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gugijihwang-Tang (the herbal formula PM012), a decoction consisting of several herbs including Rehmanniae Radix Preparata, has been widely used as herbal treatment for dementia.
In order to investigate the neuroprotective action of this prescription, we examined the effect of Gugijihwang-Tang on learning and memory using the Morris water maze and [F-18]FDG micro PET neuroimaging technique.
After injection of trimethyltin (TMT, 8.0 mg/kg, i.p.), which is a potent toxicant that selectively kills cells in the central nervous system, rats were administered Gugijihwang-Tang (100 mg/kg, p.o.) daily for two weeks, followed by the Morris water maze tasks and [F-18]FDG micro PET neuroimaging.
In Gugijihwang-Tang administered TMT-treated rats, they showed improved learning and memory abilities in water maze tasks and glucose metabolism, suggesting that Gugijihwang-Tang plays effectively positive role in the improvement of brain function including learning and memory after TMT-induced neurodegeneration.
Taken together, our results suggested that the Gugijihwang-Tang should be useful for developing strategies protecting nervous system and improving brain function.
American Psychological Association (APA)
Jung, Eun-Yee& Lee, Mi-Sook& Ahn, Chang Joon& Cho, Seung-Hun& Bae, Hyunsu& Shim, Insop. 2013. The Neuroprotective Effect of Gugijihwang-Tang on Trimethyltin-Induced Memory Dysfunction in the Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480073
Modern Language Association (MLA)
Jung, Eun-Yee…[et al.]. The Neuroprotective Effect of Gugijihwang-Tang on Trimethyltin-Induced Memory Dysfunction in the Rat. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-480073
American Medical Association (AMA)
Jung, Eun-Yee& Lee, Mi-Sook& Ahn, Chang Joon& Cho, Seung-Hun& Bae, Hyunsu& Shim, Insop. The Neuroprotective Effect of Gugijihwang-Tang on Trimethyltin-Induced Memory Dysfunction in the Rat. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480073