Extensive Differences in Antifungal Immune Response in Two Drosophila Species Revealed by Comparative Transcriptome Analysis
Joint Authors
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The innate immune system of Drosophila is activated by ingestion of microorganisms.
D.
melanogaster breeds on fruits fermented by Saccharomyces cerevisiae, whereas D.
virilis breeds on slime flux and decaying bark of tree housing a variety of bacteria, yeasts, and molds.
In this study, it is shown that D.
virilis has a higher resistance to oral infection of a species of filamentous fungi belonging to the genus Penicillium compared to D.
melanogaster.
In response to the fungal infection, a transcriptome profile of immune-related genes was considerably different between D.
melanogaster and D.
virilis: the genes encoding antifungal peptides, Drosomycin and Metchnikowin, were highly expressed in D.
melanogaster whereas, the genes encoding Diptericin and Defensin were highly expressed in D.
virilis.
On the other hand, the immune-induced molecule (IM) genes showed contrary expression patterns between the two species: they were induced by the fungal infection in D.
melanogaster but tended to be suppressed in D.
virilis.
Our transcriptome analysis also showed newly predicted immune-related genes in D.
virilis.
These results suggest that the innate immune system has been extensively differentiated during the evolution of these Drosophila species.
American Psychological Association (APA)
Seto, Yosuke& Tamura, Koichiro. 2013. Extensive Differences in Antifungal Immune Response in Two Drosophila Species Revealed by Comparative Transcriptome Analysis. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-480081
Modern Language Association (MLA)
Seto, Yosuke& Tamura, Koichiro. Extensive Differences in Antifungal Immune Response in Two Drosophila Species Revealed by Comparative Transcriptome Analysis. International Journal of Genomics No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-480081
American Medical Association (AMA)
Seto, Yosuke& Tamura, Koichiro. Extensive Differences in Antifungal Immune Response in Two Drosophila Species Revealed by Comparative Transcriptome Analysis. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-480081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480081