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Anaplastic Thyroid Cancer : A Review of Epidemiology, Pathogenesis, and Treatment
Joint Authors
Mooney, Colin J.
Nagaiah, Govardhanan
Parmentier, James
Remick, Scot C.
Hossain, Akm
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Anaplastic thyroid cancer (ATC) is an uncommon malignancy of the thyroid.
Only 1-2% of thyroid cancers are anaplastic, but the disease contributes to 14–50% of the mortality with a median survival of 3 to 5 months.
Most patients diagnosed with this disease are 65 years of age or older.
The incidence of anaplastic thyroid cancer is decreasing worldwide.
Most patients present with a rapidly growing neck mass, dysphagia, or voice change.
We performed a comprehensive literature search using PubMed focusing on the treatment of anaplastic thyroid cancer including historical review of treatment and outcomes and investigations of new agents and approaches.
A total of sixteen chart review and retrospective studies and eleven prospective studies and/or clinical trials were reviewed.
The current standard therapeutic approach is to consider the disease as systemic at time of diagnosis and pursue combined modality therapy incorporating cytoreductive surgical resection where feasible and/or chemoradiation either concurrently or sequentially.
Doxorubicin is the most commonly used agent, with a response rate of 22%.
Several new agents are currently under investigation.
Referral of patients for participation in clinical trials is needed.
American Psychological Association (APA)
Nagaiah, Govardhanan& Hossain, Akm& Mooney, Colin J.& Parmentier, James& Remick, Scot C.. 2011. Anaplastic Thyroid Cancer : A Review of Epidemiology, Pathogenesis, and Treatment. Journal of Oncology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-480091
Modern Language Association (MLA)
Nagaiah, Govardhanan…[et al.]. Anaplastic Thyroid Cancer : A Review of Epidemiology, Pathogenesis, and Treatment. Journal of Oncology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-480091
American Medical Association (AMA)
Nagaiah, Govardhanan& Hossain, Akm& Mooney, Colin J.& Parmentier, James& Remick, Scot C.. Anaplastic Thyroid Cancer : A Review of Epidemiology, Pathogenesis, and Treatment. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-480091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480091