Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke
Joint Authors
Thamotharan, G.
Sengottuvelu, S.
Bai, V. Narmatha
Mahendran, G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of the present study was to evaluate the anxiolytic, antidepressant, and anticonvulsant activity of the methanolic extract of Swertia corymbosa (SCMeOH).
After acute toxicity test, oral treatment with SCMeOH at doses of 125, 250, and 500 mg/kg behavioral models of open field, elevated-plus-maze, actophotometer, rotarod, pentylenetetrazole, isoniazid, and maximal electroshock induced seizure models were utilized.
In open field test, SCMeOH (125, 250, and 500 mg/kg) (P<0.01, P<0.001) increased the number of rearings.
However, the number of central motor and ambulation (P<0.01, P<0.001) were reduced.
Likewise, the number of entries and the time spent in open arm were increased while the number of locomotion was decreased (P<0.001) in elevated-plus-maze and actophotometer test, respectively.
SCMeOH (125–500 mg/kg) protected the mice against the pentylenetetrazole and isoniazid induced convulsions; it causes significant (P<0.01 and P<0.001) dose dependent increase in latency of convulsion.
Treatment with SCMeOH reduced the duration of the tonic hind limb extension induced by electroshock.
Two major compounds such as gentiopicroside and swertianin were analyzed by HPLC system.
American Psychological Association (APA)
Mahendran, G.& Thamotharan, G.& Sengottuvelu, S.& Bai, V. Narmatha. 2014. Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480095
Modern Language Association (MLA)
Mahendran, G.…[et al.]. Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-480095
American Medical Association (AMA)
Mahendran, G.& Thamotharan, G.& Sengottuvelu, S.& Bai, V. Narmatha. Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480095