Cytogenetic as an Important Tool for Diagnosis and Prognosis for Patients with Hypocellular Primary Myelodysplastic Syndrome
Joint Authors
Apa, Alexandre Gustavo
Corrêa de Souza, Daiane
Sobral da Costa, Elaine
Abdelhay, Eliana
Bouzas, Luis Fernando
Camargo, Adriana
de Souza Fernandez, Cecília
de Souza Fernandez, Teresa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We analyzed cytogenetically 105 patients with hypocellular primary MDS and their clinical implications.
The main chromosomal abnormalities found were del(5q)/−5, del(6q)/+6, del(7q)/−7, del(11q), and del(17p).
Pediatric patients had a higher frequency of abnormal karyotypes compared with adult patients (P < 0,05).
From our patients, 18% showed evolution of the disease.
The chromosomal abnormalities presented in the diagnosis of patients who evolved to AML included numerical (−7, +8) and structural del(6q), del(7q), i(7q), t(7;9), i(9q), and del(11q) abnormalities and complex karyotypes.
Although the frequency of evolution from hypocellular MDS to AML is low, our results suggest that some chromosomal alterations may play a critical role during this process.
We applied the IPSS in our patients because this score system has been proved to be useful for predicting evolution of disease.
When we considered the patients according to group 1 (intermediate-1) and group 2 (intermediate-2 and high risk), we showed that group 2 had a high association with respect to the frequency of abnormal karyotypes (P < 0,0001), evolution of disease (P < 0,0001), and mortality (P < 0,001).
In fact, the cytogenetic analysis for patients with hypocellular primary MDS is an important tool for diagnosis, prognosis, in clinical decision-making and in follow-up.
American Psychological Association (APA)
Corrêa de Souza, Daiane& de Souza Fernandez, Cecília& Camargo, Adriana& Apa, Alexandre Gustavo& Sobral da Costa, Elaine& Bouzas, Luis Fernando…[et al.]. 2014. Cytogenetic as an Important Tool for Diagnosis and Prognosis for Patients with Hypocellular Primary Myelodysplastic Syndrome. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-480097
Modern Language Association (MLA)
Corrêa de Souza, Daiane…[et al.]. Cytogenetic as an Important Tool for Diagnosis and Prognosis for Patients with Hypocellular Primary Myelodysplastic Syndrome. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-480097
American Medical Association (AMA)
Corrêa de Souza, Daiane& de Souza Fernandez, Cecília& Camargo, Adriana& Apa, Alexandre Gustavo& Sobral da Costa, Elaine& Bouzas, Luis Fernando…[et al.]. Cytogenetic as an Important Tool for Diagnosis and Prognosis for Patients with Hypocellular Primary Myelodysplastic Syndrome. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-480097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480097