Regulation of Signal Transduction and Role of Platelets in Liver Regeneration
Joint Authors
Ohkohchi, Nobuhiro
Nowatari, Takeshi
Fukunaga, Kiyoshi
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Among all organs, the liver has a unique regeneration capability after sustaining injury or the loss of tissue that occurs mainly due to mitosis in the hepatocytes that are quiescent under normal conditions.
Liver regeneration is induced through a cascade of various cytokines and growth factors, such as, tumor necrosis factor alpha, interleukin-6, hepatocyte growth factor, and insulin-like growth factor, which activate nuclear factor κB, signal transducer and activator of transcription 3, and phosphatidyl inositol 3-kinase signaling pathways.
We previously reported that platelets can play important roles in liver regeneration through a direct effect on hepatocytes and collaborative effects with the nonparenchymal cells of the liver, including Kupffer cells and liver sinusoidal endothelial cells, which participate in liver regeneration through the production of various growth factors and cytokines.
In this paper, the roles of platelets and nonparenchymal cells in liver regeneration, including the associated cytokines, growth factors, and signaling pathways, are described.
American Psychological Association (APA)
Nowatari, Takeshi& Fukunaga, Kiyoshi& Ohkohchi, Nobuhiro. 2012. Regulation of Signal Transduction and Role of Platelets in Liver Regeneration. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-480104
Modern Language Association (MLA)
Nowatari, Takeshi…[et al.]. Regulation of Signal Transduction and Role of Platelets in Liver Regeneration. International Journal of Hepatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-480104
American Medical Association (AMA)
Nowatari, Takeshi& Fukunaga, Kiyoshi& Ohkohchi, Nobuhiro. Regulation of Signal Transduction and Role of Platelets in Liver Regeneration. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-480104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480104