Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment
Joint Authors
Pasol, Joshua
Yang, Cui
Guy, John
Feuer, William
Kardon, Randy
Shaw, Gerry
Source
Multiple Sclerosis International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To correlate visual and neurologic clinical scores and treatment of optic neuritis and multiple sclerosis (MS) patients with assays of serum phosphorylated neurofilament heavy chain (pNF-H) and optical coherence tomography (OCT) measurements of axonal loss.
Design/Methods.
The Optic Neuritis Treatment Trial (ONTT) randomized 457 patients with acute optic neuritis to intravenous methylprednisolone (IVMP) followed by oral prednisone, oral prednisone or placebo treatment arms.
We quantified serum pNF-H levels in 175 ONTT patients 5 years after study entry.
We performed OCT measurements of macular volume and the retinal nerve fiber layer (RNFL) in a subset of 51 patients at year 15.
Results.
Elevated pNF-H levels at year 5 correlated to poorer visual function at study entry.
Lower 15 year macular volumes and RNFL thickness correlated better with follow-up than with baseline visual function measures.
With IVMP treatment, 15 year RNFL differences of the fellow eye (FE) minus the affected eye (SE) RNFLFEmSE correlated with five-year pNF-H levels.
PNF-H was reduced by half with IVMP relative to placebo or by 40% relative to prednisone.
Conclusions/Relevance.
Acute optic neuritis patients who have more severe visual loss during initial presentation have a higher incidence of axonal loss that was slightly suppressed with IVMP treatment.
American Psychological Association (APA)
Pasol, Joshua& Feuer, William& Yang, Cui& Shaw, Gerry& Kardon, Randy& Guy, John. 2011. Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment. Multiple Sclerosis International،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-480118
Modern Language Association (MLA)
Pasol, Joshua…[et al.]. Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment. Multiple Sclerosis International No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-480118
American Medical Association (AMA)
Pasol, Joshua& Feuer, William& Yang, Cui& Shaw, Gerry& Kardon, Randy& Guy, John. Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment. Multiple Sclerosis International. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-480118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480118