![](/images/graphics-bg.png)
Lm-LLO-Based Immunotherapies and HPV-Associated Disease
Joint Authors
Amin, Ashok
Wallecha, Anu
Rothman, John
French, Chris
Singh, Reshma
Petit, Robert
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
HPV infection is a direct cause of neoplasia and malignancy.
Cellular immunologic activity against cells expressing HPV E6 and E7 is sufficient to eliminate the presence of dysplastic or neoplastic tissue driven by HPV infection.
Live attenuated Listeria monocytogenes- (Lm-) based immunotherapy (ADXS11-001) has been developed for the treatment of HPV-associated diseases.
ADXS11-001 secretes an antigen-adjuvant fusion (Lm-LLO) protein consisting of a truncated fragment of the Lm protein listeriolysin O (LLO) fused to HPV-16 E7.
In preclinical models, this construct has been found to stimulate immune responses and affect therapeutic outcome.
ADXS11-001 is currently being evaluated in Phase 2 clinical trials for cervical intraepithelial neoplasia, cervical cancer, and HPV-positive head and neck cancer.
The use of a live attenuated bacterium is a more complex and complete method of cancer immunotherapy, as over millennia Lm has evolved to infect humans and humans have evolved to prevent and reject this infection over millennia.
This evolution has resulted in profound pathogen-associated immune mechanisms which are genetically conserved, highly efficacious, resistant to tolerance, and can be uniquely invoked using this novel platform technology.
American Psychological Association (APA)
Wallecha, Anu& French, Chris& Petit, Robert& Singh, Reshma& Amin, Ashok& Rothman, John. 2012. Lm-LLO-Based Immunotherapies and HPV-Associated Disease. Journal of Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480140
Modern Language Association (MLA)
Wallecha, Anu…[et al.]. Lm-LLO-Based Immunotherapies and HPV-Associated Disease. Journal of Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-480140
American Medical Association (AMA)
Wallecha, Anu& French, Chris& Petit, Robert& Singh, Reshma& Amin, Ashok& Rothman, John. Lm-LLO-Based Immunotherapies and HPV-Associated Disease. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480140