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Hypoxic-Ischemic Injury in the Developing Brain : The Role of Reactive Oxygen Species Originating in Mitochondria
Joint Authors
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mitochondrial dysfunction is the most fundamental mechanism of cell damage in cerebral hypoxia-ischemia and reperfusion.
Mitochondrial respiratory chain (MRC) is increasingly recognized as a source for reactive oxygen species (ROS) in the postischemic tissue.
Potentially, ROS originating in MRC can contribute to the reperfusion-driven oxidative stress, promoting mitochondrial membrane permeabilization.
The loss of mitochondrial membranes integrity during reperfusion is considered as the major mechanism of secondary energy failure.
This paper focuses on current data that support a pathogenic role of ROS originating from mitochondrial respiratory chain in the promotion of secondary energy failure and proposes potential therapeutic strategy against reperfusion-driven oxidative stress following hypoxia-ischemia-reperfusion injury of the developing brain.
American Psychological Association (APA)
Ten, Vadim S.& Starkov, Anatoly. 2012. Hypoxic-Ischemic Injury in the Developing Brain : The Role of Reactive Oxygen Species Originating in Mitochondria. Neurology Research International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480157
Modern Language Association (MLA)
Ten, Vadim S.& Starkov, Anatoly. Hypoxic-Ischemic Injury in the Developing Brain : The Role of Reactive Oxygen Species Originating in Mitochondria. Neurology Research International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-480157
American Medical Association (AMA)
Ten, Vadim S.& Starkov, Anatoly. Hypoxic-Ischemic Injury in the Developing Brain : The Role of Reactive Oxygen Species Originating in Mitochondria. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480157