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A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration
Joint Authors
Kemény, Lajos
Hartmann, Petra
Zupkó, István
Berkó, Szilvia
Szabó-Révész, Piroska
Németh, István
Csányi, Erzsébet
Csizmazia, Eszter
Sztojkov-Ivanov, Anita
Erős, Gábor
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Enhancement of the transdermal penetration of different active agents is an important research goal.
Our aim was to establish a novel in vivo experimental model which provides a possibility for exact measurement of the quantity of penetrated drug.
The experiments were performed on SKH-1 hairless mice.
A skin fold in the dorsal region was fixed with two fenestrated titanium plates.
A circular wound was made on one side of the skin fold.
A metal cylinder with phosphate buffer was fixed into the window of the titanium plate.
The concentration of penetrated drug was measured in the buffer.
The skin fold was morphologically intact and had a healthy microcirculation.
The drug appeared in the acceptor buffer after 30 min, and its concentration exhibited a continuous increase.
The presence of ibuprofen was also detected in the plasma.
In conclusion, this model allows an exact in vivo study of drug penetration and absorption.
American Psychological Association (APA)
Erős, Gábor& Hartmann, Petra& Berkó, Szilvia& Csizmazia, Eszter& Csányi, Erzsébet& Sztojkov-Ivanov, Anita…[et al.]. 2012. A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-480214
Modern Language Association (MLA)
Erős, Gábor…[et al.]. A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-480214
American Medical Association (AMA)
Erős, Gábor& Hartmann, Petra& Berkó, Szilvia& Csizmazia, Eszter& Csányi, Erzsébet& Sztojkov-Ivanov, Anita…[et al.]. A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-480214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480214