Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease
Joint Authors
Meirhaeghe, Aline
Arveiler, Dominique
Dallongeville, Jean
Ferrières, Jean
Amouyel, Philippe
Go, Alan S.
Fortmann, Stephen P.
Hlatky, Mark A.
Southwick, Audrey
Evans, Alun
Iribarren, Carlos
Ducimetière, Pierre
Lyon, Liisa
Quertermous, Thomas
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor γ (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes.
We assessed the relationship between 4 PPARG SNPs (C-681G, C-689T, Pro12Ala, and C1431T) and coronary heart disease (CHD) in the PRIME (249 cases/494 controls, only men) and ADVANCE (1,076 cases/805 controls, men or women) studies.
In PRIME, homozygote individuals for the minor allele of the PPARG C-689T, Pro12Ala, and C1431T SNPs tended to have a higher risk of CHD than homozygote individuals for the frequent allele (adjusted OR [95% CI] = 3.43 [0.96–12.27], P=.058, 3.41 [0.95–12.22], P=.060 and 5.10 [0.99–26.37], P=.050, resp.).
No such association could be detected in ADVANCE.
Haplotype distributions were similar in cases and control in both studies.
A meta-analysis on the Pro12Ala SNP, based on our data and 11 other published association studies (6,898 CHD cases/11,287 controls), revealed that there was no evidence for a significant association under the dominant model (OR=0.99 [0.92–1.07], P=.82).
However, there was a borderline association under the recessive model (OR=1.29 [0.99–1.67], P=.06) that became significant when considering men only (OR=1.73 [1.20–2.48], P=.003).
In conclusion, the PPARG Ala12Ala genotype might be associated with a higher CHD risk in men but further confirmation studies are needed.
American Psychological Association (APA)
Dallongeville, Jean& Iribarren, Carlos& Ferrières, Jean& Lyon, Liisa& Evans, Alun& Go, Alan S.…[et al.]. 2009. Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease. PPAR Research،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-480229
Modern Language Association (MLA)
Dallongeville, Jean…[et al.]. Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease. PPAR Research No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-480229
American Medical Association (AMA)
Dallongeville, Jean& Iribarren, Carlos& Ferrières, Jean& Lyon, Liisa& Evans, Alun& Go, Alan S.…[et al.]. Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-480229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480229