Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps
Joint Authors
de Miranda, Antonio Basílio
Guimarães, Ana Carolina Ramos
Gomes, Monete Rajão
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryps) are unicellular protozoa that cause leishmaniasis, sleeping sickness and Chagas' disease, respectively.
Most drugs against them were discovered through the screening of large numbers of compounds against whole parasites.
Nonhomologous isofunctional enzymes (NISEs) may present good opportunities for the identification of new putative drug targets because, though sharing the same enzymatic activity, they possess different three-dimensional structures thus allowing the development of molecules against one or other isoform.
From public data of the Tritryps' genomes, we reconstructed the Genetic Information Processing Pathways (GIPPs).
We then used AnEnPi to look for the presence of these enzymes between Homo sapiens and Tritryps, as well as specific enzymes of the parasites.
We identified three candidates (ECs 3.1.11.2 and 6.1.1.-) in these pathways that may be further studied as new therapeutic targets for drug development against these parasites.
American Psychological Association (APA)
Gomes, Monete Rajão& Guimarães, Ana Carolina Ramos& de Miranda, Antonio Basílio. 2011. Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps. Enzyme Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480243
Modern Language Association (MLA)
Gomes, Monete Rajão…[et al.]. Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps. Enzyme Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-480243
American Medical Association (AMA)
Gomes, Monete Rajão& Guimarães, Ana Carolina Ramos& de Miranda, Antonio Basílio. Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480243