Effect of Agaricus blazei Murill on the Pulmonary Tissue of Animals with Streptozotocin-Induced Diabetes
Joint Authors
Porawski, Marilene
Richter, Marc François
Bona, Sílvia
Di Naso, Fábio Cangeri
de Mello, Rodrigo Noronha
Ferraz, Alexandre de Barros Falcão
Marroni, Norma Anair Possa
Simões Dias, Alexandre
Source
Experimental Diabetes Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was designed to evaluate the oxidative stress as well as the therapeutic effect of Agaricus blazei Muril (A.
Blazei) in rats with streptozotocin-induced diabetes.
We used 25 Wistar rats, and DM was induced by injecting streptozotocin (70 mg/Kg i.p.).
Agaricus blazei Muril was administered daily starting 40 days after disease onset.
A.
Blazei was tested as an aqueous extract for its phytochemical composition, and its antioxidant activity in vitro was also evaluated.
Lipoperoxidation (LPO), and superoxide dismutase (SOD), catalase, and glutathione peroxidase activities were measured in the pulmonary tissue, as well as the presence of inducible nitric oxide synthase (iNOS), through immunohistochemistry.
An anatomopathologic study was also performed.
Phytochemical screening of A.
Blazei detected the presence of alkaloids and saponins.
The extract exhibited a significant antioxidant activity in the DPPH-scavenging and the hipoxanthine/xanthine oxidase assays.
Pulmonary LPO increased in diabetic animals (0.43±0.09; P<.001) as compared to the control group (0.18±0.02), followed by a reduction in the A.
Blazei-treated group (0.33±0.04; P<.05).
iNOS was found increased in the lung in diabetic rats and reduced in the A.
Blazei-treated group.
The pulmonary tissue in diabetic rats showed oxidative alterations related to the streptozotocin treatment.
The A.
Blazei treatment effectively reduced the oxidative stress and contributed to tissue recovery.
American Psychological Association (APA)
Di Naso, Fábio Cangeri& de Mello, Rodrigo Noronha& Bona, Sílvia& Simões Dias, Alexandre& Porawski, Marilene& Ferraz, Alexandre de Barros Falcão…[et al.]. 2010. Effect of Agaricus blazei Murill on the Pulmonary Tissue of Animals with Streptozotocin-Induced Diabetes. Experimental Diabetes Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-480246
Modern Language Association (MLA)
Di Naso, Fábio Cangeri…[et al.]. Effect of Agaricus blazei Murill on the Pulmonary Tissue of Animals with Streptozotocin-Induced Diabetes. Experimental Diabetes Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-480246
American Medical Association (AMA)
Di Naso, Fábio Cangeri& de Mello, Rodrigo Noronha& Bona, Sílvia& Simões Dias, Alexandre& Porawski, Marilene& Ferraz, Alexandre de Barros Falcão…[et al.]. Effect of Agaricus blazei Murill on the Pulmonary Tissue of Animals with Streptozotocin-Induced Diabetes. Experimental Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-480246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480246