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Peripheral Galanin Receptor 2 as a Target for the Modulation of Pain
Joint Authors
Hulse, Richard P.
Donaldson, Lucy F.
Wynick, David
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The neuropeptide galanin is widely expressed in the nervous system and has an important role in nociception.
It has been shown that galanin can facilitate and inhibit nociception in a dose-dependent manner, principally through the central nervous system, with enhanced antinociceptive actions after nerve injury.
However, following nerve injury, expression of galanin within the peripheral nervous system is dramatically increased up to 120-fold.
Despite this striking increase in the peripheral nervous system, few studies have investigated the role that galanin plays in modulating nociception at the primary afferent nociceptor.
Here, we summarise the recent work supporting the role of peripherally expressed galanin with particular reference to the dual actions of the galanin receptor 2 in neuropathic pain highlighting this as a potential target analgesic.
American Psychological Association (APA)
Hulse, Richard P.& Donaldson, Lucy F.& Wynick, David. 2012. Peripheral Galanin Receptor 2 as a Target for the Modulation of Pain. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-480289
Modern Language Association (MLA)
Hulse, Richard P.…[et al.]. Peripheral Galanin Receptor 2 as a Target for the Modulation of Pain. Pain Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-480289
American Medical Association (AMA)
Hulse, Richard P.& Donaldson, Lucy F.& Wynick, David. Peripheral Galanin Receptor 2 as a Target for the Modulation of Pain. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-480289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480289