Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan
Joint Authors
Tremblay-Franco, Marie
Canlet, Cécile
Molina, Jérôme
Métais, Benjamin
Gamet-Payrastre, Laurence
Blas-Y Estrada, Florence
Gautier, Roselyne
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Like other persistent organochlorine pesticides, endosulfan residues have been detected in foods including fruit, vegetables, and fish.
The aim of our study was to assess the impact of a dietary exposure to low doses of endosulfan from foetal development until adult age on metabolic homeostasis in mice and to identify biomarkers of exposure using an 1H-NMR-based metabonomic approach in various tissues and biofluids.
We report in both genders an increase in plasma glucose as well as changes in levels of factors involved in the regulation of liver oxidative stress, confirming the prooxidant activities of this compound.
Some metabolic changes were distinct in males and females.
For example in plasma, a decrease in lipid LDL and choline content was only observed in female.
Lactate levels in males were significantly increased.
In conclusion, our results show that metabolic changes in liver could be linked to the onset of pathologies like diabetes and insulin resistance.
Moreover from our results it appears that the NMR-based metabonomic approach could be useful for the characterization in plasma of a dietary exposure to low dose of pesticide in human.
American Psychological Association (APA)
Canlet, Cécile& Tremblay-Franco, Marie& Gautier, Roselyne& Molina, Jérôme& Métais, Benjamin& Blas-Y Estrada, Florence…[et al.]. 2013. Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-480322
Modern Language Association (MLA)
Canlet, Cécile…[et al.]. Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan. Journal of Toxicology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-480322
American Medical Association (AMA)
Canlet, Cécile& Tremblay-Franco, Marie& Gautier, Roselyne& Molina, Jérôme& Métais, Benjamin& Blas-Y Estrada, Florence…[et al.]. Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-480322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480322