Understanding the Mechanisms of Proteinuria : Therapeutic Implications
Joint Authors
Cao, Gabriel
Di Gennaro, F.
Bevione, P.
Angerosa, M.
Toblli, Jorge Eduardo
Madalena, L.
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A large body of evidence indicates that proteinuria is a strong predictor of morbidity, a cause of inflammation, oxidative stress and progression of chronic kidney disease, and development of cardiovascular disease.
The processes that lead to proteinuria are complex and involve factors such as glomerular hemodynamic, tubular absorption, and diffusion gradients.
Alterations in various different molecular pathways and interactions may lead to the identical clinical end points of proteinuria and chronic kidney disease.
Glomerular diseases include a wide range of immune and nonimmune insults that may target and thus damage some components of the glomerular filtration barrier.
In many of these conditions, the renal visceral epithelial cell (podocyte) responds to injury along defined pathways, which may explain the resultant clinical and histological changes.
The recent discovery of the molecular components of the slit diaphragm, specialized structure of podocyte-podocyte interaction, has been a major breakthrough in understanding the crucial role of the epithelial layer of the glomerular barrier and the pathogenesis of proteinuria.
Thispaper provides an overview and update on the structure and function of the glomerular filtration barrier and the pathogenesis of proteinuria, highlighting the role of the podocyte in this setting.
In addition, current antiproteinuric therapeutic approaches are briefly commented.
American Psychological Association (APA)
Toblli, Jorge Eduardo& Bevione, P.& Di Gennaro, F.& Madalena, L.& Cao, Gabriel& Angerosa, M.. 2012. Understanding the Mechanisms of Proteinuria : Therapeutic Implications. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-480335
Modern Language Association (MLA)
Toblli, Jorge Eduardo…[et al.]. Understanding the Mechanisms of Proteinuria : Therapeutic Implications. International Journal of Nephrology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-480335
American Medical Association (AMA)
Toblli, Jorge Eduardo& Bevione, P.& Di Gennaro, F.& Madalena, L.& Cao, Gabriel& Angerosa, M.. Understanding the Mechanisms of Proteinuria : Therapeutic Implications. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-480335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480335