Spectroscopic Evaluation of Glioma Grading at 3T : The Combined Role of Short and Long TE
Joint Authors
Fountas, K. N.
Kapsalaki, Eftychia Z.
Theodorou, Kiki
Tsougos, I.
Tsolaki, E.
Kousi, E.
Kappas, Constantin
Fezoulidis, Ioannis
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
To evaluate the diagnostic value of 3T 1H-MRS in grading cerebral gliomas using short and long echo times.
Methods.
1H-MRS was performed on 71 patients with untreated cerebral gliomas.
Metabolite ratios of NAA/Cr, Cho/Cr, Cho/NAA, and mI/Cr were calculated for short and long TE and compared between low and high grade gliomas.
Lipids were qualitatively evaluated.
ROC analysis was performed to obtain the cut-off values for the metabolic ratios presenting statistical difference between the two glioma grades.
Results.
Intratumoral Cho/Cr at both TEs and long TE Cho/NAA were significantly different between low and high grade gliomas.
Peritumoral NAA/Cr of both TEs, as well as long TE Cho/Cr and Cho/NAA ratios, significantly differentiated the two tumor grades.
Diagnostic sensitivity of peritumoral short TE NAA/Cr proved to be superior over the other metabolic ratios, whereas intratumoral short TE Cho/Cr reached the highest levels of specificity and accuracy.
Overall, short TE 1H-MRS reached higher total sensitivity in predicting glioma grade, over long TE.
Conclusion.
An advantage was found in using short TE over long TE 1H-MRS in the discrimination of low versus high grade gliomas.
Moreover, the results suggested that the peritumoral area of gliomas may be more valuable in predicting glioma grade than using only the intratumoral area.
American Psychological Association (APA)
Kousi, E.& Tsougos, I.& Tsolaki, E.& Fountas, K. N.& Theodorou, Kiki& Fezoulidis, Ioannis…[et al.]. 2012. Spectroscopic Evaluation of Glioma Grading at 3T : The Combined Role of Short and Long TE. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-480345
Modern Language Association (MLA)
Kousi, E.…[et al.]. Spectroscopic Evaluation of Glioma Grading at 3T : The Combined Role of Short and Long TE. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-480345
American Medical Association (AMA)
Kousi, E.& Tsougos, I.& Tsolaki, E.& Fountas, K. N.& Theodorou, Kiki& Fezoulidis, Ioannis…[et al.]. Spectroscopic Evaluation of Glioma Grading at 3T : The Combined Role of Short and Long TE. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-480345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480345