Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with ChitosanEudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The purpose of this study is to explore the possible applicability of Sterculia urens gum as a novel carrier for colonic delivery system of a sparingly soluble drug, azathioprine.
The study involves designing a microflora triggered colon-targeted drug delivery system (MCDDS) which consists of a central polysaccharide core and is coated to different film thicknesses with blends of chitosan/Eudragit RLPO, and is overcoated with Eudragit L00 to provide acid and intestinal resistance.
The microflora degradation property of gum was investigated in rat caecal medium.
Drug release study in simulated colonic fluid revealed that swelling force of the gum could concurrently drive the drug out of the polysaccharide core due to the rupture of the chitosan/Eudargit coating in microflora-activated environment.
Chitosan in the mixed film coat was found to be degraded by enzymatic action of the microflora in the colon.
Release kinetic data revealed that the optimized MCDDS was fitted well into first-order model, and apparent lag time was found to be 6 hours, followed by Higuchi release kinetics.
In vivo study in rabbits shows delayed Tmax, prolonged absorption time, decreased Cmax, and absorption rate constant (Ka), indicating a reduced systemic toxicity of the drug as compared to other dosage forms.
American Psychological Association (APA)
Nath, Bipul& Nath, Lila Kanta. 2012. Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with ChitosanEudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480364
Modern Language Association (MLA)
Nath, Bipul& Nath, Lila Kanta. Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with ChitosanEudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery. Journal of Pharmaceutics No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-480364
American Medical Association (AMA)
Nath, Bipul& Nath, Lila Kanta. Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with ChitosanEudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery. Journal of Pharmaceutics. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480364