α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway
Joint Authors
Li, Xuqi
Wu, Erxi
Sheng, Liang
Hu, Ang
Ma, Jiguang
Duan, Wanxing
Lei, Jianjun
Ma, Qingyong
Chen, Xin
Wang, Zheng
Wu, Zheng
Xu, Qinhong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
α-Mangostin, a natural product isolated from the pericarp of the mangosteen fruit, has been shown to inhibit the growth of tumor cells in various types of cancers.
However, the underlying molecular mechanisms are largely unclear.
Here, we report that α-mangostin suppressed the viability and epithelial-mesenchymal transition (EMT) of pancreatic cancer cells through inhibition of the PI3K/Akt pathway.
Treatment of pancreatic cancer BxPc-3 and Panc-1 cells with α-mangostin resulted in loss of cell viability, accompanied by enhanced cell apoptosis, cell cycle arrest at G1 phase, and decrease of cyclin-D1.
Moreover, Transwell and Matrigel invasion assays showed that α-mangostin significantly reduced the migration and invasion of pancreatic cancer cells.
Consistent with these results, α-mangostin decreased the expression of MMP-2, MMP-9, N-cadherin, and vimentin and increased the expression of E-cadherin.
Furthermore, we found that α-mangostin suppressed the activity of the PI3K/Akt pathway in pancreatic cancer cells as demonstrated by the reduction of the Akt phosphorylation by α-mangostin.
Finally, α-mangostin significantly inhibited the growth of BxPc-3 tumor mouse xenografts.
Our results suggest that α-mangostin may be potentially used as a novel adjuvant therapy or complementary alternative medicine for the management of pancreatic cancers.
American Psychological Association (APA)
Xu, Qinhong& Ma, Jiguang& Lei, Jianjun& Duan, Wanxing& Sheng, Liang& Chen, Xin…[et al.]. 2014. α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480366
Modern Language Association (MLA)
Xu, Qinhong…[et al.]. α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-480366
American Medical Association (AMA)
Xu, Qinhong& Ma, Jiguang& Lei, Jianjun& Duan, Wanxing& Sheng, Liang& Chen, Xin…[et al.]. α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480366