Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model
Joint Authors
al-Asmi, Abdullah
Essa, Musthafa Mohamed
al-Adawi, Samir
Vaishnav, Ragini
Subash, Selvaraju
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer’s disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test.
AD Tg mice on control diet without figs showed significant impairment in spatial learning ability compared to the wild-type mice on same diet and figs fed Tg mice as well.
Significant increase in oxidative stress and reduced antioxidant status were observed in AD Tg mice.
4% figs treated AD Tg mice significantly attenuated oxidative damage, as evident by decreased lipid peroxidation and protein carbonyls and restoration of antioxidant status.
Altered activities of membrane bound enzymes (Na+ K+ ATPase and acetylcholinesterase (AChE)) in AD Tg mice brain regions and was restored by figs treatment.
Further, figs supplementation might be able to decrease the plasma levels of Aβ (1–40, 1–42) significantly in Tg mice suggesting a putative delay in the formation of plaques, which might be due to the presence of high natural antioxidants in figs.
But this study warrants further extensive investigation to find a novel lead for a therapeutic target for AD from figs.
American Psychological Association (APA)
Subash, Selvaraju& Essa, Musthafa Mohamed& al-Asmi, Abdullah& al-Adawi, Samir& Vaishnav, Ragini. 2014. Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480368
Modern Language Association (MLA)
Subash, Selvaraju…[et al.]. Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-480368
American Medical Association (AMA)
Subash, Selvaraju& Essa, Musthafa Mohamed& al-Asmi, Abdullah& al-Adawi, Samir& Vaishnav, Ragini. Chronic Dietary Supplementation of 4% Figs on the Modification of Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480368