Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action
Joint Authors
Bandyopadhyay, Sandip K.
Chattopadhyay, Subrata
Adhikary, Biplab
Yadav, Sudhir Kumar
Roy, Kshama
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The healing activities of black tea (BT) and the theaflavins (TF) against the indomethacin-induced stomach ulceration were studied in a mouse model.
Indomethacin (18 mg/kg, p.o.) administration induced maximum ulceration in the glandular portion of the gastric mucosa on the 3rd day, accompanied by increased lipid peroxidation and protein oxidation, depletion of thiol-defense and mucin, as well as reduced expressions of cyclooxygenases (COX) and prostaglandin (PG) E synthesis in the gastric tissues, and plasma total antioxidant status of mice.
Treatment with BT (40 mg/kg), TF (1 mg/kg), and omeprazole (3 mg/kg) produced similar (74%–76%) ulcer healing, as revealed from the histopathological studies.
Treatment with all the above samples reversed the adverse oxidative effects of indomethacin significantly.
BT and TF also enhanced the PGE synthesis by augmenting the expressions of COX 1 and 2, but did not modulate acid secretion.
American Psychological Association (APA)
Adhikary, Biplab& Yadav, Sudhir Kumar& Roy, Kshama& Bandyopadhyay, Sandip K.& Chattopadhyay, Subrata. 2010. Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480389
Modern Language Association (MLA)
Adhikary, Biplab…[et al.]. Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-480389
American Medical Association (AMA)
Adhikary, Biplab& Yadav, Sudhir Kumar& Roy, Kshama& Bandyopadhyay, Sandip K.& Chattopadhyay, Subrata. Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480389