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Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization : Pathogenetic Interactions and Therapeutic Implications
Joint Authors
Semeraro, Francesco
Sheridan, Carl
Costagliola, Ciro
Campa, Claudio
Incorvaia, Carlo
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Choroidal neovascularization (CNV) is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration.
Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved.
Experimental and clinical evidences show that vascular endothelial growth factor is a key signal in promoting angiogenesis.
However, many other molecules, distinctive of the inflammatory response, act as neovascular activators in CNV.
These include fibroblast growth factor, transforming growth factor, tumor necrosis factor, interleukins, and complement.
This paper reviews the role of inflammatory mediators and angiogenic factors in the development of CNV, proposing pathogenetic assumptions of mutual interaction.
As an extension of this concept, new therapeutic approaches geared to have an effect on both the vascular and the extravascular components of CNV are discussed.
American Psychological Association (APA)
Campa, Claudio& Costagliola, Ciro& Incorvaia, Carlo& Sheridan, Carl& Semeraro, Francesco. 2010. Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization : Pathogenetic Interactions and Therapeutic Implications. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-480405
Modern Language Association (MLA)
Campa, Claudio…[et al.]. Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization : Pathogenetic Interactions and Therapeutic Implications. Mediators of Inflammation No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-480405
American Medical Association (AMA)
Campa, Claudio& Costagliola, Ciro& Incorvaia, Carlo& Sheridan, Carl& Semeraro, Francesco. Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization : Pathogenetic Interactions and Therapeutic Implications. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-480405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480405