Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia
Joint Authors
Zhan, Wang
Weiner, Michael W.
Ching, Christopher
Schuff, Norbert
Kramer, Joel H.
Tosun, Duygu
Rosen, Howard J.
Gorno-Tempini, Maria Luisa
Nezamzadeh, Marzieh
Miller, Bruce L.
Zhang, Yu
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Most MRI studies of Alzheimer's disease (AD) and frontotemporal dementia (FTD) have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities.
This paper aimed to assess brain gray (GM) and white matter (WM) abnormalities jointly to elucidate differences in abnormal MRI patterns between the diseases.
Twenty AD, 20 FTD patients, and 21 healthy control subjects were imaged using a 4 Tesla MRI.
GM loss and GM hypoperfusion were measured using high-resolution T1 and arterial spin labeling MRI (ASL-MRI).
WM degradation was measured with diffusion tensor imaging (DTI).
Using a new analytical approach, the study found greater WM degenerations in FTD than AD at mild abnormality levels.
Furthermore, the GM loss and WM degeneration exceeded the reduced perfusion in FTD whereas, in AD, structural and functional damages were similar.
Joint assessments of multimodal MRI have potential value to provide new imaging markers for improved differential diagnoses between FTD and AD.
American Psychological Association (APA)
Zhang, Yu& Schuff, Norbert& Ching, Christopher& Tosun, Duygu& Zhan, Wang& Nezamzadeh, Marzieh…[et al.]. 2011. Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480408
Modern Language Association (MLA)
Zhang, Yu…[et al.]. Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-480408
American Medical Association (AMA)
Zhang, Yu& Schuff, Norbert& Ching, Christopher& Tosun, Duygu& Zhan, Wang& Nezamzadeh, Marzieh…[et al.]. Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480408