The Redox System in C. elegans, a Phylogenetic Approach
Joint Authors
Ebert, Paul R.
Johnston, Andrew D.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS).
ROS cause oxidative damage to cellular components such as proteins, lipids, and nucleic acids.
While the role of ROS in cellular damage is frequently all that is noted, ROS are also important in redox signalling.
The “Redox Hypothesis" has been proposed to emphasize a dual role of ROS.
This hypothesis suggests that the primary effect of changes to the redox state is modified cellular signalling rather than simply oxidative damage.
In extreme cases, alteration of redox signalling can contribute to the toxicity of ROS, as well as to ageing and age-related diseases.
The nematode species Caenorhabditis elegans provides an excellent model for the study of oxidative stress and redox signalling in animals.
We use protein sequences from central redox systems in Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae to query Genbank for homologous proteins in C.
elegans.
We then use maximum likelihood phylogenetic analysis to compare protein families between C.
elegans and the other organisms to facilitate future research into the genetics of redox biology.
American Psychological Association (APA)
Johnston, Andrew D.& Ebert, Paul R.. 2012. The Redox System in C. elegans, a Phylogenetic Approach. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-480412
Modern Language Association (MLA)
Johnston, Andrew D.& Ebert, Paul R.. The Redox System in C. elegans, a Phylogenetic Approach. Journal of Toxicology No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-480412
American Medical Association (AMA)
Johnston, Andrew D.& Ebert, Paul R.. The Redox System in C. elegans, a Phylogenetic Approach. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-480412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480412