Are Mesenchymal Cells Indeed Pluripotent Stem Cells or Just Stromal Cells? OCT-4 and VSELs Biology Has Led to Better Understanding
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Stem cells have excited researchers because of their potential to regenerate.
However, which stem cells will be the best candidate for regenerative medicine remains an enigma.
Compared to pluripotent stem cells with associated risks of immune rejection and teratoma formation, adult stem cells especially the mesenchymal stem cells (MSCs) are hyped to be a suitable alternate since they also exhibit pluripotent properties.
This review shows that there is a subpopulation of pluripotent very small embryonic-like stem cells (VSELs) among MSCs culture.
The two populations differ from each other in expression pattern of OCT-4.
VSELs exhibit nuclear OCT-4A, whereas the MSCs have cytoplasmic OCT-4B, similar to our earlier findings in testis and ovary.
Pluripotent VSELs with nuclear OCT-4A exist in various adult body organs, and the immediate progenitors express cytoplasmic OCT-4B which is eventually lost as the cell differentiates further.
To conclude it is essential to discriminate between nuclear and cytoplasmic OCT-4 expression and also to acknowledge the presence of VSELs.
American Psychological Association (APA)
Bhartiya, Deepa. 2013. Are Mesenchymal Cells Indeed Pluripotent Stem Cells or Just Stromal Cells? OCT-4 and VSELs Biology Has Led to Better Understanding. Stem Cells International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480465
Modern Language Association (MLA)
Bhartiya, Deepa. Are Mesenchymal Cells Indeed Pluripotent Stem Cells or Just Stromal Cells? OCT-4 and VSELs Biology Has Led to Better Understanding. Stem Cells International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-480465
American Medical Association (AMA)
Bhartiya, Deepa. Are Mesenchymal Cells Indeed Pluripotent Stem Cells or Just Stromal Cells? OCT-4 and VSELs Biology Has Led to Better Understanding. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-480465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480465