Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing
Joint Authors
Delgado, Alfonso
Bobadilla-Lugo, Rosa Amalia
Alatorre, Alberto
Ríos, Alain
Oviedo-Chávez, Aldo
Querejeta, Enrique
Barrientos, Rafael
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The globus pallidus (GP) plays a key role in the overall basal ganglia (BG) activity.
Despite evidence of cholinergic inputs to GP, their role in the spiking activity of GP neurons has not received attention.
We examine the effect of local activation and blockade of muscarinic receptors (MRs) in the spontaneous firing of GP neurons both in normal and ipsilateral striatum-lesioned rats.
We found that activation of MRs produces heterogeneous responses in both normal and ipsilateral striatum-lesioned rats: in normal rats the response evoked by MRs depends on the predrug basal firing rate; the inhibition evoked by MRs is higher in normal rats than in striatum-lesioned rats; the number of neurons that undergo inhibition is lower in striatum-lesioned rats than in normal rats.
Our data suggest that modulation of MRs in the GP depends on the firing rate before their activation and on the integrity of the striato-pallidal pathway.
American Psychological Association (APA)
Querejeta, Enrique& Alatorre, Alberto& Ríos, Alain& Barrientos, Rafael& Oviedo-Chávez, Aldo& Bobadilla-Lugo, Rosa Amalia…[et al.]. 2012. Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480482
Modern Language Association (MLA)
Querejeta, Enrique…[et al.]. Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-480482
American Medical Association (AMA)
Querejeta, Enrique& Alatorre, Alberto& Ríos, Alain& Barrientos, Rafael& Oviedo-Chávez, Aldo& Bobadilla-Lugo, Rosa Amalia…[et al.]. Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480482