Molecular Mechanisms Underlying the Link between Nuclear Receptor Function and Cholesterol Gallstone Formation
Joint Authors
Rigotti, Attilio
Vázquez, Mary Carmen
Zanlungo, Silvana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cholesterol gallstone disease is highly prevalent in western countries, particularly in women and some specific ethnic groups.
The formation of water-insoluble cholesterol crystals is due to a misbalance between the three major lipids present in the bile: cholesterol, bile salts, and phospholipids.
Many proteins implicated in biliary lipid secretion in the liver are regulated by several transcription factors, including nuclear receptors LXR and FXR.
Human and murine genetic, physiological, pathophysiological, and pharmacological evidence is consistent with the relevance of these nuclear receptors in gallstone formation.
In addition, there is emerging data that also suggests a role for estrogen receptor ESR1 in abnormal cholesterol metabolism leading to gallstone disease.
A better comprehension of the role of nuclear receptor function in gallstone formation may help to design new and more effective therapeutic strategies for this highly prevalent disease condition.
American Psychological Association (APA)
Vázquez, Mary Carmen& Rigotti, Attilio& Zanlungo, Silvana. 2011. Molecular Mechanisms Underlying the Link between Nuclear Receptor Function and Cholesterol Gallstone Formation. Journal of Lipids،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480483
Modern Language Association (MLA)
Vázquez, Mary Carmen…[et al.]. Molecular Mechanisms Underlying the Link between Nuclear Receptor Function and Cholesterol Gallstone Formation. Journal of Lipids No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-480483
American Medical Association (AMA)
Vázquez, Mary Carmen& Rigotti, Attilio& Zanlungo, Silvana. Molecular Mechanisms Underlying the Link between Nuclear Receptor Function and Cholesterol Gallstone Formation. Journal of Lipids. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480483