Specific Link between Lung and Large Intestine : A New Perspective on Neuropeptide Secretion in Lung with Herbal Laxative Stimulation
Joint Authors
Zhong, Xiang-Gen
Wang, Qian
Liu, Miao
Xu, Hong
Zheng, Feng-Jie
Liu, Yu-Chao
Gao, Si-hua
Zhang, Shu-Jing
Gao, Yu-Shan
Zhang, Tian-Yu
Li, Yu-Hang
Zhang, Jin-Chao
Wu, Ruo-Han
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
To investigate the specific link between lung and large intestine.
Methods.
Rat COPD-like model was prepared.
Mirabilite or Chinese rhubarb was administrated intragastrically to stimulate the large intestine.
Histological analysis of lung inflammation was assessed.
The tissues levels of SP, VIP, NK1R, VIPR1, and VIPR2 were measured by using ELISA kits.
In addition, mouse model of allergic asthma was prepared.
Mirabilite was administrated intragastrically to stimulate the large intestine.
Airway responsiveness and lung inflammation were assessed.
The tissues levels of SP, VIP, NKA, NKB, NK1R, VIPR1, and VIPR2 were measured by using ELISA kits.
Results.
Stimulating the intestine with Mangxiao or Dahuang, SP, NK-1R, VIP, VIPR1, and VIPR2 were significantly increased in intestine tissues of rats with COPD and mice with asthma.
Meanwhile, the SP and NK1R were significantly decreased, while VIP, VIPR1, and VIPR2 were significantly increased in lung tissues.
An abnormal secretion of SP and VIP can be observed in other tissues; however, no marked changes were found in the receptors.
The NKA and NKB levels were similar in lung tissues of mice with asthma among groups.
Conclusions.
Stimulating intestine with Mangxiao or Dahuang can specifically regulate the secretion of SP, VIP, and the receptors in lung tissues.
American Psychological Association (APA)
Zhong, Xiang-Gen& Zheng, Feng-Jie& Li, Yu-Hang& Xu, Hong& Wang, Qian& Liu, Yu-Chao…[et al.]. 2013. Specific Link between Lung and Large Intestine : A New Perspective on Neuropeptide Secretion in Lung with Herbal Laxative Stimulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480490
Modern Language Association (MLA)
Zhong, Xiang-Gen…[et al.]. Specific Link between Lung and Large Intestine : A New Perspective on Neuropeptide Secretion in Lung with Herbal Laxative Stimulation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-480490
American Medical Association (AMA)
Zhong, Xiang-Gen& Zheng, Feng-Jie& Li, Yu-Hang& Xu, Hong& Wang, Qian& Liu, Yu-Chao…[et al.]. Specific Link between Lung and Large Intestine : A New Perspective on Neuropeptide Secretion in Lung with Herbal Laxative Stimulation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480490