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Posttranslational Protein Modification in the Salivary Glands of Sjögren’s Syndrome Patients
Joint Authors
Badillo-Soto, Martha Adriana
Rodríguez-Rodríguez, Mayra
Bollain-y-Goytia, Juan José
Herrera-Esparza, Rafael
Pérez-Pérez, María Elena
Avalos-Díaz, Esperanza
Torres-del-Muro, Felipe
Pacheco-Tovar, Deyanira
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study investigated posttranslational reactions in the salivary glands of patients with Sjögren’s syndrome.
We analysed the biopsies of primary Sjögren’s patients using immunohistochemistry and a tag-purified anticyclic citrullinated protein (CCP) antibody to detect citrullinated peptides, and the presence of peptidylarginine deiminase 2 (PAD2) was assessed simultaneously.
The present work demonstrated the weak presence of the PAD2 enzyme in some normal salivary glands, although PAD2 expression was increased considerably in Sjögren’s patients.
The presence of citrullinated proteins was also detected in the salivary tissues of Sjögren’s patients, which strongly supports the in situ posttranslational modification of proteins in this setting.
Furthermore, the mutual expression of CCP and PAD2 suggests that this posttranslational modification is enzyme dependent.
In conclusion, patients with Sjögren’s syndrome expressed the catalytic machinery to produce posttranslational reactions that may result in autoantigen triggering.
American Psychological Association (APA)
Herrera-Esparza, Rafael& Rodríguez-Rodríguez, Mayra& Pérez-Pérez, María Elena& Badillo-Soto, Martha Adriana& Torres-del-Muro, Felipe& Bollain-y-Goytia, Juan José…[et al.]. 2013. Posttranslational Protein Modification in the Salivary Glands of Sjögren’s Syndrome Patients. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-480509
Modern Language Association (MLA)
Herrera-Esparza, Rafael…[et al.]. Posttranslational Protein Modification in the Salivary Glands of Sjögren’s Syndrome Patients. Autoimmune Diseases No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-480509
American Medical Association (AMA)
Herrera-Esparza, Rafael& Rodríguez-Rodríguez, Mayra& Pérez-Pérez, María Elena& Badillo-Soto, Martha Adriana& Torres-del-Muro, Felipe& Bollain-y-Goytia, Juan José…[et al.]. Posttranslational Protein Modification in the Salivary Glands of Sjögren’s Syndrome Patients. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-480509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480509