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Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats : A Positron Emission Tomography Study Using [18F]MK-9470
Joint Authors
Zavitsanou, Katerina
Verdurand, Mathieu
Gregoire, Marie-Claude
Stark, Daniela
Nguyen, Vu
Greguric, Ivan
Zahra, David
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Despite the important role of cannabinoid CB1 receptors (CB1R) in brain development, little is known about their status during adolescence, a critical period for both the development of psychosis and for initiation to substance abuse.
In the present study, we assessed the ontogeny of CB1R in adolescent and adult rats in vivo using positron emission tomography with [18F]MK-9470.
Analysis of covariance (ANCOVA) to control for body weight that would potentially influence [18F]MK-9470 values between the two groups revealed a main effect of age (F(1,109)=5.0, P=0.02) on [18F]MK-9470 absolute binding (calculated as percentage of injected dose) with adult estimated marginal means being higher compared to adolescents amongst 11 brain regions.
This finding was confirmed using in vitro autoradiography with [3H]CP55,940 (F(10,99)=140.1, P<0.0001).
This ontogenetic pattern, suggesting increase of CB1R during the transition from adolescence to adulthood, is the opposite of most other neuroreceptor systems undergoing pruning during this period.
American Psychological Association (APA)
Verdurand, Mathieu& Nguyen, Vu& Stark, Daniela& Zahra, David& Gregoire, Marie-Claude& Greguric, Ivan…[et al.]. 2011. Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats : A Positron Emission Tomography Study Using [18F]MK-9470. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480518
Modern Language Association (MLA)
Verdurand, Mathieu…[et al.]. Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats : A Positron Emission Tomography Study Using [18F]MK-9470. International Journal of Molecular Imaging No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-480518
American Medical Association (AMA)
Verdurand, Mathieu& Nguyen, Vu& Stark, Daniela& Zahra, David& Gregoire, Marie-Claude& Greguric, Ivan…[et al.]. Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats : A Positron Emission Tomography Study Using [18F]MK-9470. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480518