Using Epidemiology and Genomics to Understand Osteosarcoma Etiology
Joint Authors
Savage, Sharon A.
Mirabello, Lisa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Osteosarcoma is a primary bone malignancy that typically occurs during adolescence but also has a second incidence peak in the elderly.
It occurs most commonly in the long bones, although there is variability in location between age groups.
The etiology of osteosarcoma is not well understood; it occurs at increased rates in individuals with Paget disease of bone, after therapeutic radiation, and in certain cancer predisposition syndromes.
It also occurs more commonly in taller individuals, but a strong environmental component to osteosarcoma risk has not been identified.
Several studies suggest that osteosarcoma may be associated with single nucleotide polymorphisms in genes important in growth and tumor suppression but the studies are limited by sample size.
Herein, we review the epidemiology of osteosarcoma as well as its known and suspected risk factors in an effort to gain insight into its etiology.
American Psychological Association (APA)
Savage, Sharon A.& Mirabello, Lisa. 2011. Using Epidemiology and Genomics to Understand Osteosarcoma Etiology. Sarcoma،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-480523
Modern Language Association (MLA)
Savage, Sharon A.& Mirabello, Lisa. Using Epidemiology and Genomics to Understand Osteosarcoma Etiology. Sarcoma No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-480523
American Medical Association (AMA)
Savage, Sharon A.& Mirabello, Lisa. Using Epidemiology and Genomics to Understand Osteosarcoma Etiology. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-480523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480523