Mechanisms of Amyloid-Beta Peptide Uptake by Neurons : The Role of Lipid Rafts and Lipid Raft-Associated Proteins
Joint Authors
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A hallmark pathological feature of Alzheimer's disease (AD) is the accumulation of extracellular plaques composed of the amyloid-beta (Aβ) peptide.
Thus, classically experiments were designed to examine Aβ toxicities within the central nervous system (CNS) from the extracellular space.
However, a significant amount of evidence now suggests that intraneuronal accumulation of Aβ is neurotoxic and may play an important role in the disease progression of AD.
One of the means by which neurons accumulate intracellular Aβ is through uptake of extracellular Aβ peptides, and this process may be a potential link between Aβ generation, synaptic dysfunction, and AD pathology.
Recent studies have found that neuronal internalization of Aβ involves lipid rafts and various lipid raft-associated receptor proteins.
Uptake mechanisms independent of lipid rafts have also been implicated.
The aim of this paper is to summarize these findings and discuss their significance in the pathogenesis of AD.
American Psychological Association (APA)
Lai, Aaron Y.& McLaurin, JoAnne. 2010. Mechanisms of Amyloid-Beta Peptide Uptake by Neurons : The Role of Lipid Rafts and Lipid Raft-Associated Proteins. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480554
Modern Language Association (MLA)
Lai, Aaron Y.& McLaurin, JoAnne. Mechanisms of Amyloid-Beta Peptide Uptake by Neurons : The Role of Lipid Rafts and Lipid Raft-Associated Proteins. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-480554
American Medical Association (AMA)
Lai, Aaron Y.& McLaurin, JoAnne. Mechanisms of Amyloid-Beta Peptide Uptake by Neurons : The Role of Lipid Rafts and Lipid Raft-Associated Proteins. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-480554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480554