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Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity
Joint Authors
Liu, Helene Minyi
Gale, Michael
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Exposure to hepatitis C virus (HCV) usually results in persistent infection that often develops into chronic liver disease.
Interferon-alpha (IFN) treatment comprises the foundation of current approved therapy for chronic HCV infection but is limited in overall efficacy.
IFN is a major effector of innate antiviral immunity and is naturally produced in response to viral infection when viral pathogen-associated molecular patterns (PAMPs) are recognized as nonself and are bound by cellular pathogen recognition receptors (PRRs), including Toll-like receptors (TLRs) and the RIG-I-like receptors (RLRs).
Within hepatocytes, RIG-I is a major PRR of HCV infection wherein PAMP interactions serve to trigger intracellular signaling cascades in the infected hepatocyte to drive IFN production and the expression of interferon-stimulated genes (ISGs).
ISGs function to limit virus replication, modulate the immune system, and to suppress virus spread.
However, studies of HCV-host interactions have revealed several mechanisms of innate immune regulation and evasion that feature virus control of PRR signaling and regulation of hepatic innate immune programs that may provide a molecular basis for viral persistence.
American Psychological Association (APA)
Liu, Helene Minyi& Gale, Michael. 2011. Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-480556
Modern Language Association (MLA)
Liu, Helene Minyi& Gale, Michael. Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity. Gastroenterology Research and Practice No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-480556
American Medical Association (AMA)
Liu, Helene Minyi& Gale, Michael. Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity. Gastroenterology Research and Practice. 2011. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-480556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480556