Loss of Microstructural Integrity in the Limbic-Subcortical Networks for Acute Symptomatic Traumatic Brain Injury
Joint Authors
Li, Zhengjun
Zhang, Ming
Zheng, Longmei
Sun, Chuanzhu
Bai, Lijun
Zhu, Bao
Zhou, Heping
Yao, Jun
Zhu, Yanan
Tao, Yin
Li, Min
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Previous studies reported discrepant white matter diffusivity in mild traumatic brain injury (mTBI) on the base of Glasgow Coma Scale, which are unreliable for some TBI severity indicators and the frequency of missing documentation in the medical record.
In the present study, we adopted the Mayo classification system for TBI severity.
In this system, the mTBI is also divided into two groups as “probable and symptomatic” TBI.
We aimed to investigate altered microstructural integrity in symptomatic acute TBI (<1 week) by using tract-based spatial statics (TBSS) approach.
A total of 12 patients and 13 healthy volunteers were involved and underwent MRI scans including conventional scan, and SWI and DTI.
All the patients had no visible lesions by using conventional and SWI neuroimaging techniques, while showing widespread declines in the fractional anisotropy (FA) of gray matter and white matter throughout the TBSS skeleton, particularly in the limbic-subcortical structures.
By contrast, symptomatic TBI patients showed no significant enhanced changes in FA compared to the healthy controls.
A better understanding of the acute changes occurring following symptomatic TBI may increase our understanding of neuroplasticity and continuing degenerative change, which, in turn, may facilitate advances in management and intervention.
American Psychological Association (APA)
Zhu, Yanan& Li, Zhengjun& Bai, Lijun& Tao, Yin& Sun, Chuanzhu& Li, Min…[et al.]. 2014. Loss of Microstructural Integrity in the Limbic-Subcortical Networks for Acute Symptomatic Traumatic Brain Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480557
Modern Language Association (MLA)
Zhu, Yanan…[et al.]. Loss of Microstructural Integrity in the Limbic-Subcortical Networks for Acute Symptomatic Traumatic Brain Injury. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-480557
American Medical Association (AMA)
Zhu, Yanan& Li, Zhengjun& Bai, Lijun& Tao, Yin& Sun, Chuanzhu& Li, Min…[et al.]. Loss of Microstructural Integrity in the Limbic-Subcortical Networks for Acute Symptomatic Traumatic Brain Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480557