Brain Imaging of Nicotinic Receptors in Alzheimer's Disease
Joint Authors
Ishikawa, Masatomo
Wu, Jin
Zhang, Jichun
Hashimoto, Kenji
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels which are widely distributed in the human brain.
Several lines of evidence suggest that two major subtypes (α4β2 and α7) of nAChRs play an important role in the pathophysiology of Alzheimer's disease (AD).
Postmortem studies demonstrated alterations in the density of these subtypes of nAChRs in the brain of patients with AD.
Currently, nAChRs are one of the most attractive therapeutic targets for AD.
Therefore, several researchers have made an effort to develop novel radioligands that can be used to study quantitatively the distribution of these two subtypes in the human brain with positron emission tomography (PET) and single-photon emission computed tomography (SPECT).
In this paper, we discuss the current topics on in vivo imaging of two subtypes of nAChRs in the brain of patients with AD.
American Psychological Association (APA)
Wu, Jin& Ishikawa, Masatomo& Zhang, Jichun& Hashimoto, Kenji. 2010. Brain Imaging of Nicotinic Receptors in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-480602
Modern Language Association (MLA)
Wu, Jin…[et al.]. Brain Imaging of Nicotinic Receptors in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-480602
American Medical Association (AMA)
Wu, Jin& Ishikawa, Masatomo& Zhang, Jichun& Hashimoto, Kenji. Brain Imaging of Nicotinic Receptors in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-480602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480602