AMPK-Dependent Metabolic Regulation by PPAR Agonists
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARα, PPARβ/δ, and PPARγ, regulate cell growth, morphogenesis, differentiation, and homeostasis.
Agonists of each PPAR subtype exert their effects similarly or distinctly in different tissues such as liver, muscle, fat, and vessels.
It is noteworthy that PPARα or PPARγ agonists have pharmacological effects by modulating the activity of AMPK, which is a key cellular energy sensor.
However, the role of AMPK in the metabolic effects of PPAR agonists has not been thoroughly focused.
Moreover, AMPK activation by PPAR agonists seems to be independent of the receptor activation.
This intriguing action of PPAR agonists may account in part for the mechanistic basis of the therapeutics in the treatment of metabolic disease.
In this paper, the effects of PPAR agonists on metabolic functions were summarized with particular reference to their AMPK activity regulation.
American Psychological Association (APA)
Lee, Woo Hyung& Kim, Sang Geon. 2010. AMPK-Dependent Metabolic Regulation by PPAR Agonists. PPAR Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-480626
Modern Language Association (MLA)
Lee, Woo Hyung& Kim, Sang Geon. AMPK-Dependent Metabolic Regulation by PPAR Agonists. PPAR Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-480626
American Medical Association (AMA)
Lee, Woo Hyung& Kim, Sang Geon. AMPK-Dependent Metabolic Regulation by PPAR Agonists. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-480626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480626