Stem Cell Based Gene Therapy in Prostate Cancer
Joint Authors
Kim, Jae Heon
Song, Yun Seob
Lee, Hong Jun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Current prostate cancer treatment, especially hormone refractory cancer, may create profound iatrogenic outcomes because of the adverse effects of cytotoxic agents.
Suicide gene therapy has been investigated for the substitute modality for current chemotherapy because it enables the treatment targeting the cancer cells.
However the classic suicide gene therapy has several profound side effects, including immune-compromised due to viral vector.
Recently, stem cells have been regarded as a new upgraded cellular vehicle or vector because of its homing effects.
Suicide gene therapy using genetically engineered mesenchymal stem cells or neural stem cells has the advantage of being safe, because prodrug administration not only eliminates tumor cells but consequently kills the more resistant therapeutic stem cells as well.
The attractiveness of prodrug cancer gene therapy by stem cells targeted to tumors lies in activating the prodrug directly within the tumor mass, thus avoiding systemic toxicity.
Therapeutic achievements using stem cells in prostate cancer include the cytosine deaminase/5-fluorocytosine prodrug system, herpes simplex virus thymidine kinase/ganciclovir, carboxyl esterase/CPT11, and interferon-beta.
The aim of this study is to review the stem cell therapy in prostate cancer including its proven mechanisms and also limitations.
American Psychological Association (APA)
Kim, Jae Heon& Lee, Hong Jun& Song, Yun Seob. 2014. Stem Cell Based Gene Therapy in Prostate Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480631
Modern Language Association (MLA)
Kim, Jae Heon…[et al.]. Stem Cell Based Gene Therapy in Prostate Cancer. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-480631
American Medical Association (AMA)
Kim, Jae Heon& Lee, Hong Jun& Song, Yun Seob. Stem Cell Based Gene Therapy in Prostate Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480631