Antibacterial Activity of Rhus javanica against Methicillin-Resistant Staphylococcus aureus
Joint Authors
You, Yong-Ouk
Kim, Kang-Ju
Kang, Sun-Young
Choi, Na-Young
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the present study, the leaves of Rhus javanica (R.
javanica) were extracted with ethanol, and we investigated the antimicrobial activity of the ethanol extract of R.
javanica against methicillin-resistant Staphylococcus aureus (MRSA).
Control groups were treated with media containing 0.1% DMSO.
The ethanol extract of R.
javanica inhibited the growth of MRSA at concentrations ranging from 0.05 to 0.2 mg/mL and inhibited acid production at concentrations higher than 0.1 mg/mL (P<0.05).
MRSA biofilm formation was determined by scanning electron microscopy and safranin staining.
The ethanol extract of R.
javanica inhibited the formation of MRSA biofilms at concentrations higher than 0.05 mg/mL.
In confocal laser scanning microscopy, high concentration (0.4–1.6 mg/mL) of R.
javanica extract showed bactericidal effect in a dose-dependent manner.
In real-time PCR analysis, R.
javanica extract showed the inhibition of the genetic expression of virulence factors such as mecA, sea, agrA, and sarA in MRSA.
Preliminary phytochemical analysis revealed the strong presence of phenolics.
These results suggest that R.
javanica may be a useful medicinal plant for inhibiting MRSA, which may be related to the presence of phenolics in the R.
javanica extract.
American Psychological Association (APA)
You, Yong-Ouk& Choi, Na-Young& Kang, Sun-Young& Kim, Kang-Ju. 2013. Antibacterial Activity of Rhus javanica against Methicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-480641
Modern Language Association (MLA)
You, Yong-Ouk…[et al.]. Antibacterial Activity of Rhus javanica against Methicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-480641
American Medical Association (AMA)
You, Yong-Ouk& Choi, Na-Young& Kang, Sun-Young& Kim, Kang-Ju. Antibacterial Activity of Rhus javanica against Methicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-480641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480641