![](/images/graphics-bg.png)
Isoniazid Toxicity among an Older Veteran Population : A Retrospective Cohort Study
Joint Authors
Linkin, Darren R.
Maslow, Joel
Vinnard, Christopher
Gopal, Anand
Source
Tuberculosis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background: our objective was to determine the incidence of toxicity among veterans initiating isoniazid therapy for latent tuberculosis infection (LTBI) and determine whether advancing age was a risk factor for toxicity.
Methods: we performed a retrospective cohort study among all adults initiating isoniazid treatment for LTBI at a Veterans Medical Center from 1999 to 2005.
We collected data on patient demographics, co-morbidities, site of initiation, and treatment outcome.
Results: 219 patients initiated isoniazid therapy for LTBI during the period of observation, and the completion of therapy was confirmed in 100 patients (46%).
Among 18/219 patients (8%) that discontinued therapy due to a documented suspected toxicity, the median time to onset was 3 months (IQR 1–5 months).
In an adjusted Cox regression model, there was no association between discontinuation due to suspected toxicity and advancing age (HR 1.03, 95% CI 0.99, 1.07).
In contrast, hepatitis C infection was a significant predictor of cessation due to toxicity in the adjusted analysis (HR 3.03, 95% CI 1.08, 8.52).
Conclusions: cessation of isoniazid therapy due to suspected toxicity was infrequently observed among a veteran population and was not associated with advancing age.
Alternative LTBI treatment approaches should be further examined in the veteran population.
American Psychological Association (APA)
Vinnard, Christopher& Gopal, Anand& Linkin, Darren R.& Maslow, Joel. 2013. Isoniazid Toxicity among an Older Veteran Population : A Retrospective Cohort Study. Tuberculosis Research and Treatment،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-480668
Modern Language Association (MLA)
Vinnard, Christopher…[et al.]. Isoniazid Toxicity among an Older Veteran Population : A Retrospective Cohort Study. Tuberculosis Research and Treatment No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-480668
American Medical Association (AMA)
Vinnard, Christopher& Gopal, Anand& Linkin, Darren R.& Maslow, Joel. Isoniazid Toxicity among an Older Veteran Population : A Retrospective Cohort Study. Tuberculosis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-480668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480668