BMPs as Therapeutic Targets and Biomarkers in Astrocytic Glioma
Joint Authors
Mira, Helena
Anselmo, Nilson Praia
González-Gómez, Pilar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Astrocytic glioma is the most common brain tumor.
The glioma initiating cell (GIC) fraction of the tumor is considered as highly chemoresistant, suggesting that GICs are responsible for glioma relapse.
A potential treatment for glioma is to induce differentiation of GICs to a more benign and/or druggable cell type.
Given BMPs are among the most potent inducers of GIC differentiation, they have been considered as noncytotoxic therapeutic compounds that may be of use to prevent growth and recurrence of glioma.
We herein summarize advances made in the understanding of the role of BMP signaling in astrocytic glioma, with a particular emphasis on the effects exerted on GICs.
We discuss the prognostic value of BMP signaling components and the implications of BMPs in the differentiation of GICs and in their sensitization to alkylating drugs and oncolytic therapy/chemotherapy.
This mechanistic insight may provide new opportunities for therapeutic intervention of brain cancer.
American Psychological Association (APA)
González-Gómez, Pilar& Anselmo, Nilson Praia& Mira, Helena. 2014. BMPs as Therapeutic Targets and Biomarkers in Astrocytic Glioma. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480701
Modern Language Association (MLA)
González-Gómez, Pilar…[et al.]. BMPs as Therapeutic Targets and Biomarkers in Astrocytic Glioma. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-480701
American Medical Association (AMA)
González-Gómez, Pilar& Anselmo, Nilson Praia& Mira, Helena. BMPs as Therapeutic Targets and Biomarkers in Astrocytic Glioma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480701