![](/images/graphics-bg.png)
miR-320 Regulates Glucose-Induced Gene Expression in Diabetes
Joint Authors
Chakrabarti, Subrata K.
Feng, Biao
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
miRNAs play an important role in several biological processes.
Here, we investigated miR-320 in glucose-induced augmented production of vasoactive factors and extracellular matrix (ECM) proteins.
High glucose exposure decreased the expression of microRNA 320 (miR-320) but increased the expression of endothelin 1 (ET-1), vascular endothelial growth factor (VEGF), and fibronectin (FN) in human umbilical vein endothelial cells (HUVECs).
Transfection of miR-320 mimics restored ET-1, VEGF and FN mRNA, and protein expression in HUVECs treated with high glucose.
Furthermore, miR-320 mimic transfection reduced glucose-induced augmented production of ERK1/2.
Data from this study indicates that miR-320 negatively regulates expression of ET-1, VEGF, and FN through ERK 1/2.
Identification of such novel glucose-induced mechanism regulating gene expression may offer a new strategy for the treatment of diabetic complications.
American Psychological Association (APA)
Feng, Biao& Chakrabarti, Subrata K.. 2012. miR-320 Regulates Glucose-Induced Gene Expression in Diabetes. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-480725
Modern Language Association (MLA)
Feng, Biao& Chakrabarti, Subrata K.. miR-320 Regulates Glucose-Induced Gene Expression in Diabetes. ISRN Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-480725
American Medical Association (AMA)
Feng, Biao& Chakrabarti, Subrata K.. miR-320 Regulates Glucose-Induced Gene Expression in Diabetes. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-480725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480725