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Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain : Technical and Clinical Overview
Joint Authors
García-Lozano, Juan Carlos
Peciña, Ana
Antiñolo, Guillermo
Lozano-Arana, Maria Dolores
Guardiola, Jordi
Borrego, Salud
Sánchez, Beatriz
Fernández, Raquel María
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Preimplantation genetic diagnosis (PGD) of genetic diseases, combined with HLA matching (PGD-HLA), is an option for couples at risk of transmitting a genetic disease to select unaffected embryos of an HLA tissue type compatible with that of an existing affected child.
Here we present the results of our PGD-HLA program at the Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Rocío in Seville.
Seven couples have participated in our program because of different indications.
Overall, 26 cycles were performed, providing a total of 202 embryos.
A conclusive molecular diagnosis and HLA-typing could be assured in 96% of the embryos.
The percentage of transfers per cycle was 26.9% and the birth rate per cycle was 7.7% per transfer.
Our PGD-HLA program resulted in the birth of 2 healthy babies, HLA-identical to their affected siblings, with successful subsequent haematopoietic stem cell (HSC) transplantations.
Both HSC-transplanted children are currently doing well 48 and 21 months following transplantation, respectively.
All the procedures, including HSCs umbilical cord transplantation, were performed in our hospital.
American Psychological Association (APA)
Fernández, Raquel María& Peciña, Ana& Lozano-Arana, Maria Dolores& Sánchez, Beatriz& Guardiola, Jordi& García-Lozano, Juan Carlos…[et al.]. 2014. Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain : Technical and Clinical Overview. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480734
Modern Language Association (MLA)
Fernández, Raquel María…[et al.]. Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain : Technical and Clinical Overview. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-480734
American Medical Association (AMA)
Fernández, Raquel María& Peciña, Ana& Lozano-Arana, Maria Dolores& Sánchez, Beatriz& Guardiola, Jordi& García-Lozano, Juan Carlos…[et al.]. Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain : Technical and Clinical Overview. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480734