The Effect of Multiple Single Nucleotide Polymorphisms in the Folic Acid Pathway Genes on Homocysteine Metabolism
Joint Authors
Zhou, Yuanpeng
Yu, Chen
Wang, Huijun
Tian, Weidong
Zhou, Shufeng
Liang, Shuang
Persaud-Sharma, Vishwani
Li, Xiaotian
Ma, Duan
Ren, Yunyun
Qian, Yanyan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism.
Methods.
Four hundred women with normal pregnancies were enrolled in this study.
SNPs were identified by MassARRAY.
Serum folic acid and Hcy concentration were measured.
Analysis of variance (ANOVA) and support vector machine (SVM) regressions were used to analyze the joint effects of SNPs on the Hcy level.
Results.
SNPs of MTHFR (rs1801133 and rs3733965) were significantly associated with maternal serum Hcy level.
In the different genotypes of MTHFR (rs1801133), SNPs of RFC1 (rs1051266), TCN2 (rs9606756), BHMT (rs3733890), and CBS (rs234713 and rs2851391) were linked with the Hcy level adjusted for folic acid concentration.
The integrated SNPs scores were significantly associated with the residual Hcy concentration (RHC) (r=0.247).
The Hcy level was significantly higher in the group with high SNP scores than that in other groups with SNP scores of less than 0.2 (P=0.000).
Moreover, this difference was even more significant in moderate and high levels of folic acid.
Conclusion.
SNPs of genes in the folic acid pathway possibly affect the Hcy metabolism in the presence of moderate and high levels of folic acid.
American Psychological Association (APA)
Liang, Shuang& Zhou, Yuanpeng& Wang, Huijun& Qian, Yanyan& Ma, Duan& Tian, Weidong…[et al.]. 2014. The Effect of Multiple Single Nucleotide Polymorphisms in the Folic Acid Pathway Genes on Homocysteine Metabolism. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480738
Modern Language Association (MLA)
Liang, Shuang…[et al.]. The Effect of Multiple Single Nucleotide Polymorphisms in the Folic Acid Pathway Genes on Homocysteine Metabolism. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-480738
American Medical Association (AMA)
Liang, Shuang& Zhou, Yuanpeng& Wang, Huijun& Qian, Yanyan& Ma, Duan& Tian, Weidong…[et al.]. The Effect of Multiple Single Nucleotide Polymorphisms in the Folic Acid Pathway Genes on Homocysteine Metabolism. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480738