Feasibility of Treating Irradiated Bone with Intramedullary Delivered Autologous Mesenchymal Stem Cells
Joint Authors
Poussier, Sylvain
Dolivet, Gilles
Bravetti, Pierre
Graff, Pierre
Merlin, Jean-Louis
Tran, Nguyen
Huger, Sandrine
Marie, Pierre-Yves
Phulpin, Bérengère
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
We aimed to explore (i) the short-term retention of intramedullary implanted mesenchymal stem cells BMSCs and (ii) their impact on the bone blood flow and metabolism in a rat model of hindlimb irradiation.
Methods.
Three months after 30 Gy irradiation, fourteen animals were referred into 2 groups: a sham-operated group (n= 6) and a treated group (n= 8) in which 111In-labelled BMSCs (2×106 cells) were injected in irradiated tibias.
Bone blood flow and metabolism were assessed by serial T99mc-HDP scintigraphy and 1-wk cell retention by recordings of T99mc/111In activities.
Results.
The amount of intramedullary implanted BMSCs was of 70% at 2 H, 40% at 48 H, and 38% at 168 H.
Bone blood flow and bone metabolism were significantly increased during the first week after cell transplantation, but these effects were found to reduce at 2-mo followup.
Conclusion.
Short-term cell retention produced concomitant enhancement in irradiated bone blood flow and metabolism.
American Psychological Association (APA)
Phulpin, Bérengère& Dolivet, Gilles& Marie, Pierre-Yves& Poussier, Sylvain& Huger, Sandrine& Bravetti, Pierre…[et al.]. 2011. Feasibility of Treating Irradiated Bone with Intramedullary Delivered Autologous Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480747
Modern Language Association (MLA)
Phulpin, Bérengère…[et al.]. Feasibility of Treating Irradiated Bone with Intramedullary Delivered Autologous Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-480747
American Medical Association (AMA)
Phulpin, Bérengère& Dolivet, Gilles& Marie, Pierre-Yves& Poussier, Sylvain& Huger, Sandrine& Bravetti, Pierre…[et al.]. Feasibility of Treating Irradiated Bone with Intramedullary Delivered Autologous Mesenchymal Stem Cells. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480747