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Alternative Splicing in Self-Renewal of Embryonic Stem Cells
Joint Authors
Cheong, Clara Y.
Lufkin, Thomas
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Much of embryonic stem cell biology has focused on transcriptional expression and regulation of genes that could mediate its unique potential in self-renewal or pluripotency.
In alignment with our present understanding on the genetic, protein, and epigenetic factors that may direct cell fate, we present a short overview of the often overlooked contribution of alternative splice variants to regulatory diversity.
Progressing beyond the limitations of a fixed genomic sequence, alternative splicing offers an additional layer of complexity to produce protein variants that may differ in function and localization that can direct embryonic stem cells to specific differentiation pathways.
In light of the number of variants that can be produced at key ES cell genes alone, it is challenging to consider how much more multifaceted transcriptional regulation truly is, and if this can be captured more fully in future works.
American Psychological Association (APA)
Cheong, Clara Y.& Lufkin, Thomas. 2011. Alternative Splicing in Self-Renewal of Embryonic Stem Cells. Stem Cells International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480749
Modern Language Association (MLA)
Cheong, Clara Y.& Lufkin, Thomas. Alternative Splicing in Self-Renewal of Embryonic Stem Cells. Stem Cells International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-480749
American Medical Association (AMA)
Cheong, Clara Y.& Lufkin, Thomas. Alternative Splicing in Self-Renewal of Embryonic Stem Cells. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480749