Macrophage Plasticity in Skeletal Muscle Repair
Joint Authors
Brunelli, Silvia
Rovere-Querini, Patrizia
Zordan, Paola
Rigamonti, Elena
Sciorati, Clara
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Macrophages are one of the first barriers of host defence against pathogens.
Beyond their role in innate immunity, macrophages play increasingly defined roles in orchestrating the healing of various injured tissues.
Perturbations of macrophage function and/or activation may result in impaired regeneration and fibrosis deposition as described in several chronic pathological diseases.
Heterogeneity and plasticity have been demonstrated to be hallmarks of macrophages.
In response to environmental cues they display a proinflammatory (M1) or an alternative anti-inflammatory (M2) phenotype.
A lot of evidence demonstrated that after acute injury M1 macrophages infiltrate early to promote the clearance of necrotic debris, whereas M2 macrophages appear later to sustain tissue healing.
Whether the sequential presence of two different macrophage populations results from a dynamic shift in macrophage polarization or from the recruitment of new circulating monocytes is a subject of ongoing debate.
In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle.
American Psychological Association (APA)
Rigamonti, Elena& Zordan, Paola& Sciorati, Clara& Rovere-Querini, Patrizia& Brunelli, Silvia. 2014. Macrophage Plasticity in Skeletal Muscle Repair. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480789
Modern Language Association (MLA)
Rigamonti, Elena…[et al.]. Macrophage Plasticity in Skeletal Muscle Repair. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-480789
American Medical Association (AMA)
Rigamonti, Elena& Zordan, Paola& Sciorati, Clara& Rovere-Querini, Patrizia& Brunelli, Silvia. Macrophage Plasticity in Skeletal Muscle Repair. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480789