PPARs Signaling and Cancer in the Gastrointestinal System

Abstract EN

Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest.

From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models.

In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.